Based on the history, it was around mid 20th century, and that is when the medical community acknowledge autoimmune disease. All along the first half of the century, the disease (autoimmune) was considered/seen as biologically incredible,
Back in the 1950s, Henry G. Kunkel started examining people with rheumatoid arthritis and lupus. Scientists question whether antibodies is in opposition to a person's own tissues even existed.
Kunkel and his coworkers began using the most recent developed tools of protein chemistry. They demonstrated a certain antibody from the blood of people facing rheumatoid arthritis (RA), and how it reacted with other antibodies, presumably if they were antigens (the RA factor).
When discovered that in the synovial fluid of the joints, it resulted a complex, that is where inflammation begun. Kunkel, himself also identified and representing countless antibodies in lupus. Precisely, he found immune complexes that increased in the kidneys of lupus patients, effecting a disease.
A beginner from clinical immunology, through his career, Kunkel constructed an inspiration from studying patients, as well as using his clinical visions to analyze the bottom principles of immunology.
Comentários